Question
Superantigens
Answer :
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Superantigens are a unique class of antigens that provoke an unusually strong immune response by directly linking major histocompatibility complex (MHC) class II molecules on antigen-presenting cells with T-cell receptors (TCRs) on T lymphocytes, bypassing the normal antigen processing pathway. Unlike conventional antigens, which activate a small, specific subset of T cells, superantigens can activate up to 20-30% of the total T-cell population, leading to massive cytokine release, known as a cytokine storm. This excessive immune activation can
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