Question
Describe the structure and function of MHC molecules
Answer :
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Major Histocompatibility Complex (MHC) molecules are cell surface glycoproteins essential for the adaptive immune response. They are classified into two main classes: MHC class I and MHC class II, each differing in structure, expression patterns, and immune functions. MHC class I molecules are expressed on almost all nucleated cells and consist of a heavy α-chain with three extracellular domains (α1, α2, α3) non-covalently associated with β2-microglobulin. The α1 and α2 domains form a peptide-binding groove that accommodates endogenous peptides, typically 8–10 amino acids long, derived from
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