Question
What is the role of the variant surface glycoprotein (VSG) family in African Trypanosomes survival against host immune system?
Answer :
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African trypanosomes survive within the mammalian host primarily through the expression of variant surface glycoproteins, which form a dense protective coat over the parasite’s cell membrane. The VSG family plays a central role in immune evasion by enabling antigenic variation, a process through which the parasite repeatedly changes the antigenic identity of its surface. At any given time, an individual trypanosome expresses only a single type
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