Adult schistosomes have evolved multiple sophisticated strategies to evade and overcome the host’s immunological responses, enabling their long-term survival within the bloodstream. One major approach is molecular mimicry, where adult worms acquire host antigens such as blood group substances and major histocompatibility complex molecules on their tegument, making them appear immunologically similar to host tissues and reducing immune recognition. The tegument itself is a dynamic, metabolically active surface that is continuously renewed, allowing shedding of antibody-bound molecules and minimizing immune-mediated damage. Another important mechanism is immunomodulation. Adult schistosomes secrete excretory–secretory products that interfere with host immune signaling pathways, suppressing effective