IGNOU MZOE 001 2026 - Write a short note on humoral and cellular response in human body agai

Question

Write a short note on humoral and cellular response in human body against adult hookworms.

29 Jan 2026

Answer :

Word Count : 491

Adult hookworms residing in the human intestine induce a complex immune response that involves both humoral and cellular components, although the parasite has evolved mechanisms to evade complete elimination. The immune response is typically biased toward a Th2-type profile, which is characteristic of helminth infections and plays a significant role in limiting parasite burden and associated pathology. The humoral immune response against adult hookworms is marked by the production of specific antibodies, particularly IgE, IgG, and IgA. IgE plays a central role by binding to antigens released or expressed by adult worms. These IgE molecules attach to high-affinity Fc receptors on mast cells, basophils, and eosinophils. Upon re-exposure

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