Question
What is the factors affecting biotransformation of drugs?.
Answer :
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Biotransformation of drugs refers to the chemical alteration of drugs in the body, mainly carried out by liver enzymes, to convert lipid-soluble drugs into water-soluble metabolites for excretion. Several factors affect the rate and extent of biotransformation. Age is an important factor. In newborns, enzyme systems are not fully developed, so drug metabolism is slow. In elderly patients, liver function decreases, resulting in reduced metabolism. Genetic factors also influence drug biotransformation. Some individuals possess inherited variations in drug-metabolizing enzymes, causing fast or slow metabolism of drugs. Species differences affect metabolism because animals and humans metabolize drugs differently due to variation in enzyme systems. Sex hormones can also
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