Floodplain wetlands are dynamic ecosystems formed along the floodplains of rivers through seasonal flooding, sediment deposition, and fluctuations in water levels. In the Indian subcontinent, these wetlands have played a crucial role in shaping human settlements, agricultural systems, livelihoods, biodiversity, and cultural traditions. The relationship between humans and floodplain wetlands has evolved over thousands of years, reflecting changing ecological conditions, technological developments, political interventions, and economic priorities. Environmental history provides a valuable perspective for understanding how these interactions have transformed landscapes while simultaneously influencing social, economic, and ecological systems. The floodplains of major river systems such as the Ganga, Brahmaputra, Indus, Mahanadi, Godavari, Krishna, and Kaveri contain numerous wetlands including oxbow lakes, marshes, swamps, seasonal ponds, and backwaters. These wetlands are naturally created by river dynamics and annual floods, making them among the most productive ecosystems in the Indian subcontinent. Their fertility, abundant water resources, and biodiversity have attracted human settlements since prehistoric times. Archaeological evidence suggests that early agricultural communities established settlements near rivers and wetlands because these environments provided reliable water, fertile alluvial soils, fish, edible plants, and wildlife. Floodplain wetlands reduced the risks associated with drought by storing water during rainy seasons and releasing it gradually during dry periods. This ecological stability encouraged permanent settlement and agricultural expansion. Agriculture has historically depended upon floodplain wetlands in multiple ways. Seasonal floods deposited nutrient-rich silt on adjoining lands, reducing the need for artificial fertilizers. Farmers cultivated rice, wheat, pulses, oilseeds, vegetables, and other crops in fertile floodplains. Wetlands also served as natural irrigation reservoirs, supporting cultivation even after floodwaters receded. Traditional farming systems evolved in harmony with natural flood cycles, allowing communities to utilize periodic inundation without permanently altering river systems. Fishing communities have maintained intimate relationships with floodplain wetlands for centuries. Wetlands support diverse fish species, crustaceans, molluscs, turtles, and aquatic plants that provide food and income. Seasonal fisheries became important components of local economies in Bengal, Assam, Bihar, Uttar Pradesh, and many other regions. Indigenous fishing practices were often regulated by customary institutions that controlled harvesting seasons and protected breeding grounds, contributing to sustainable resource management. Floodplain wetlands also supplied numerous non-fish resources. Local communities collected reeds, grasses, bamboo, medicinal plants, lotus stems, water chestnuts, fodder, fuelwood, and clay. These resources supported household economies, handicrafts, livestock rearing, and traditional medicine. Women frequently played a central role in gathering wetland resources, highlighting the gendered dimensions of human-environment interactions. Livestock grazing represented another important aspect of wetland use. During dry seasons, exposed grasslands within floodplains provided nutritious pasture for cattle, buffaloes, goats, and sheep. Animal husbandry complemented agriculture through the recycling of nutrients, while wetlands supplied water for livestock throughout the year. Such integrated production systems reflected a balanced relationship between ecological processes and rural livelihoods. Floodplain wetlands have also possessed immense cultural and religious significance. Rivers and associated wetlands are regarded as sacred in many Indian traditions. Numerous temples, pilgrimage centres, festivals, and rituals developed around riverine landscapes. Sacred groves, ponds, tanks, and marshes often received protection because of religious beliefs, indirectly conserving biodiversity and ecological functions. Communities associated flood cycles with agricultural prosperity and divine blessings, embedding ecological rhythms within cultural practices. Traditional ecological knowledge played a significant role in managing floodplain wetlands.