Question
Abnormal Haemoglobins
Answer :
Word Count : 494
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Haemoglobin is a complex protein present in red blood cells that transports oxygen from the lungs to body tissues and carries carbon dioxide back to the lungs. It consists of four globin chains, each associated with a haem group containing iron. In normal adults, the major haemoglobin is HbA, composed of two alpha (α) and two beta (β) chains. Abnormal haemoglobins are structurally or functionally altered forms of haemoglobin produced due to mutations in the genes coding for globin chains. They are important in human genetics because many are inherited disorders that can cause haemolytic anaemia and other clinical abnormalities. Abnormal haemoglobins may result from changes in the amino acid sequence of a globin chain, reduced production of a globin chain, or abnormal regulation of haemoglobin synthesis. Structural haemoglobin variants generally arise from
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