Climate change has emerged as one of the most pressing global challenges of the twenty-first century, fundamentally altering the relationship between human societies and the natural environment. Its impacts are not uniform, as they vary across regions, populations, and ecosystems, creating uneven vulnerabilities and risks. Vulnerability assessment, which refers to the systematic evaluation of the susceptibility of individuals, communities, or systems to harm from climate-related hazards, has become essential for guiding adaptation policies and resilience strategies. However, assessing vulnerability is a complex task because climate change does not act in isolation; it interacts with pre-existing social, economic, political, and ecological conditions. Human health, infrastructure, agriculture, and biodiversity are four sectors where the challenges of conducting accurate and comprehensive vulnerability assessments are particularly significant, as each sector faces unique pressures, data limitations, and uncertainties. Human health is among the most directly affected areas when considering climate vulnerability. Climate change increases the frequency and intensity of extreme heat events, floods, droughts, and storms, each of which poses distinct health risks. Heatwaves contribute to rising incidences of heat stress, dehydration, and cardiovascular problems, particularly among vulnerable populations such as the elderly, children, and those with pre-existing illnesses. Floods and hurricanes can lead not only to immediate injuries and fatalities but also to long-term health consequences due to contamination of water supplies, spread of vector-borne diseases, and disruption of healthcare infrastructure. However, assessing vulnerability in this sector is challenging because health outcomes are mediated by multiple factors, including socioeconomic status, public health infrastructure, urban design, and individual adaptive capacities. For example, two communities exposed to the same climate hazard may experience very different health impacts depending on the availability of medical facilities, quality of housing, access to clean water, and effectiveness of early warning systems. Moreover, health impacts often manifest indirectly; rising temperatures expand the habitat range of mosquitoes, thereby increasing the prevalence of diseases such as malaria or dengue in regions previously unaffected. Predicting the spread and incidence of such diseases under different climate scenarios is highly complex, as it depends not only on climate variables but also on patterns of human migration, land-use change, and local governance capacity. Thus, vulnerability assessment in the health sector requires interdisciplinary data from climatology, epidemiology, sociology, and economics, yet such integrative approaches often face methodological and institutional barriers. Infrastructure, which encompasses transportation networks, energy systems, water supply facilities, and urban settlements, represents another sector where vulnerability assessments are both crucial and challenging. Climate change threatens infrastructure through multiple pathways, including rising sea levels, storm surges, flooding, and heat-induced degradation of materials. Coastal infrastructure, such as ports, bridges, and highways, is at particular risk of inundation and erosion due to sea-level rise. In urban areas, drainage systems may be overwhelmed by more frequent and intense rainfall events, leading to flooding that damages roads, electricity grids, and communication networks. Assessing infrastructure vulnerability requires not only physical measurements of exposure to hazards but also an understanding of interdependencies among systems. For instance, if a storm disrupts electricity supply, it