Question
What is there in the 5th position of deoxyhemoglobin? Explain with a suitable diagram. Give the relevant equations for the equilibrium constant regarding the oxygen binding by myoglobin.
Answer :
Word Count : 237
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In deoxyhemoglobin, the 5th coordination position of the central iron(II) ion in the heme group is occupied by the nitrogen atom of the proximal histidine residue from the globin protein. The heme iron is in a square pyramidal geometry in deoxyhemoglobin, with four nitrogen atoms of the porphyrin ring in the plane and the fifth position bound to the proximal histidine. The sixth coordination site remains vacant in deoxyhemoglobin, allowing it to bind molecular oxygen when
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