Question
Modification in DNA and Hisntones
Answer :
Word Count : 234
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DNA and histone modifications are crucial epigenetic mechanisms that regulate gene expression without altering the underlying DNA sequence. DNA modification primarily involves the addition of a methyl group to the 5-carbon of cytosine residues, forming 5-methylcytosine. This methylation commonly occurs at CpG dinucleotides and is catalyzed by DNA methyltransferases (DNMTs). DNA methylation generally represses transcription by preventing the binding of transcription factors or recruiting proteins that compact chromatin structure, thereby reducing gene accessibility. Demethylation, either passive or active via ten-eleven
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