Question
Hot spot Mutation
Answer :
Word Count : 258
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A hot spot mutation refers to a region in the genome that exhibits a significantly higher frequency of mutations compared to other regions. These mutations are not random but occur repeatedly at specific nucleotide sites due to inherent structural, chemical, or functional properties of DNA. Hot spots are commonly observed in both prokaryotic and eukaryotic genomes and play an important role in genetic variation, evolution, and disease development. At the molecular level, hot spot mutations often arise because certain DNA sequences are more prone to chemical modification or replication errors.
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