IGNOU BBCCT 123 2026 - Explain the physiological significance of regulated protein degradatio

Question

Explain the physiological significance of regulated protein degradation in cell cycle control and stress responses.

09 Feb 2026

Answer :

Word Count : 247

Regulated protein degradation is essential for maintaining cellular homeostasis by ensuring that specific proteins are removed at the right time. In the context of cell cycle control, proteins that promote progression through the cell cycle must be precisely regulated to avoid uncontrolled cell division. Cyclins, for example, activate cyclin-dependent kinases (CDKs) at specific phases of the cell cycle. Their degradation at the end of each phase ensures that the cell does not prematurely re-enter the same phase. This regulated degradation is primarily carried out by the ubiquitin-proteasome pathway, which tags proteins for degradation through ubiquitin molecules.

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