Question

 Discuss how wobble base pairing allows efficient translation with a limited number of tRNAs.

10 Feb 2026
Answer :
Word Count : 266
The genetic code consists of 64 codons, of which 61 specify amino acids, but most cells contain far fewer than 61 distinct tRNAs. This efficiency is made possible by wobble base pairing, a mechanism that allows a single tRNA to recognize multiple codons coding for the same amino acid. According to Crick’s wobble hypothesis, strict Watson–Crick base pairing occurs between the first two bases of the codon
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