Question
Define Cyclin-CDKs kinases. Write a brief note on the relationship between cyclin and CDKs.
Answer :
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Cyclin-dependent kinases (CDKs) are a family of serine/threonine protein kinases that play a central role in regulating progression through the cell cycle. By themselves, CDKs are catalytically inactive enzymes. Their kinase activity is dependent on binding to regulatory proteins known as cyclins, hence the term cyclin-CDK kinases. Once activated, cyclin-CDK complexes phosphorylate specific target proteins involved in DNA replication, mitosis, transcription, and cell cycle checkpoints, thereby ensuring orderly and unidirectional cell cycle progression. The relationship between cyclins and CDKs is highly specific and tightly regulated. Cyclins are synthesized
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