IGNOU MBCE 13 2026 - Explain the biochemical basis of muscle fatigue during prolo

Question

Explain the biochemical basis of muscle fatigue during prolonged physical activity.

21 Jan 2026

Answer :

Word Count : 243

Muscle fatigue during prolonged physical activity arises from a complex interplay of biochemical processes that impair the muscle’s ability to sustain contraction. Initially, muscle contraction depends on the availability of adenosine triphosphate (ATP), which provides the immediate energy for cross-bridge cycling. During intense or sustained activity, ATP consumption exceeds its rate of regeneration, leading to a transient energy deficit. As ATP levels fall, adenosine diphosphate (ADP) and inorganic phosphate (Pi) accumulate within the muscle fibers. The elevated Pi

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