Question
Which organ is the principal site of urea formation? Explain the urea cycle.
Answer :
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The liver is the principal organ responsible for urea formation in the body. It plays a central role in the detoxification of ammonia, a toxic byproduct of amino acid catabolism. Ammonia is highly toxic to cells, particularly to the brain, and must be efficiently converted into a less toxic form for excretion. The urea cycle, also known as the ornithine cycle, is the metabolic pathway by which ammonia is converted into urea in the liver.
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