Question
What is Homology modeling? Discuss briefly any one tool used in homology modelling.
Answer :
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Homology modeling is a structural bioinformatics approach used to predict the three-dimensional structure of a protein based on its sequence similarity with a known template structure. In OMICS research, especially within proteomics and structural genomics, homology modeling helps bridge the gap between the vast number of protein sequences generated through high-throughput sequencing and the relatively limited number of experimentally determined protein structures. The fundamental assumption is that proteins sharing a significant level of sequence identity will also share similar overall folding patterns and conserved structural motifs. The process generally involves
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