Question
Nitration of benzothiophene
Answer :
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Nitration of benzothiophene is an electrophilic aromatic substitution reaction where a nitro group is introduced into the heteroaromatic benzothiophene ring. Benzothiophene consists of a benzene ring fused with a thiophene ring, and the sulfur atom strongly influences the electron density distribution. Due to the presence of sulfur, the thiophene ring becomes more reactive than the benzene ring, directing electrophilic substitution preferentially at the 2-position. The nitration is carried out using a nitrating mixture such as concentrated nitric acid and
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