Question
Explain the Ran GTP/GDP Cycle.
Answer :
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The Ran GTP/GDP cycle is a critical regulatory mechanism in eukaryotic cells that controls nucleocytoplasmic transport, mitotic spindle assembly, and nuclear envelope formation. Ran is a small GTP-binding protein of the Ras superfamily, existing in two states: Ran-GTP (active) and Ran-GDP (inactive). The distribution of these forms is asymmetric across the nuclear envelope, which is essential for directional transport of proteins and RNA. In the nucleus, Ran exists predominantly as Ran-GTP due to the presence of RanGEF (Ran guanine nucleotide exchange factor), also known
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