Question
Explain Negishi coupling reaction with an example and give its mechanism.
Answer :
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The Negishi coupling reaction is a palladium- or nickel-catalyzed cross-coupling reaction used to form carbon–carbon bonds between an organozinc compound and an organic halide or pseudohalide. It is an important method in organic synthesis because organozinc reagents are relatively stable, less basic, and highly functional-group tolerant compared to organolithium or Grignard reagents. The reaction is widely applied in the synthesis of biaryls, alkenes, and complex molecules in pharmaceuticals and natural products. In a typical example, phenylzinc bromide reacts with bromobenzene in the presence of a
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