Question
Discuss Bischer synthesis of indole. How can you obtain a single product in this reaction?
Answer :
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Fischer indole synthesis is an important method for the preparation of indole and substituted indoles from aryl hydrazines and aldehydes or ketones under acidic conditions. In this reaction, an aryl hydrazine first reacts with a carbonyl compound to form a hydrazone. On heating with a strong acid such as hydrochloric acid, sulfuric acid, or polyphosphoric acid,
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