Bryophytes, comprising mosses, liverworts, and hornworts, represent some of the earliest land plants and have been traditionally valued for their medicinal properties due to their bioactive compounds. These non-vascular plants contain secondary metabolites such as terpenoids, flavonoids, alkaloids, phenolic compounds, and essential oils, which contribute to their therapeutic applications. Many bryophytes produce substances that exhibit antibacterial, antifungal, antiviral, antioxidant, and anti-inflammatory activities, making them significant in traditional and modern medicine. Certain liverworts, such as *Marchantia polymorpha*, have been used historically in wound healing. The thallus of *Marchantia* contains compounds with antimicrobial properties that prevent infections and aid in tissue regeneration. Extracts of *Marchantia* have been studied for their potential to inhibit bacterial growth, especially against pathogens responsible for skin infections. Similarly, mosses like *Polytrichum* species have been applied in folk medicine as