Question
Draw TCA cycle and write the equation showing net outcome of this cycle. Also calculate how many ATPs are produced by aerobic oxidation of one glucose molecule?
Answer :
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The tricarboxylic acid cycle is the central oxidative pathway of carbohydrate and lipid metabolism and takes place in the mitochondrial matrix. Acetyl CoA, formed from pyruvate, fatty acids, or amino acids, condenses with oxaloacetate to form citrate. Citrate is isomerized to isocitrate, which undergoes oxidative decarboxylation to form α-ketoglutarate with the release of carbon dioxide and formation of NADH. α-Ketoglutarate is further oxidatively decarboxylated to succinyl CoA, producing another molecule of carbon dioxide and NADH. Succinyl CoA is converted to succinate with the generation of GTP. Succinate is oxidized to fumarate producing
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