Question
Discuss the compounds other than pyruvate which can serve as gluconeogenic precursors.
Answer :
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Gluconeogenesis is the metabolic pathway through which glucose is synthesized from non-carbohydrate precursors, ensuring a constant supply of glucose during fasting or intense exercise. While pyruvate is a primary substrate for gluconeogenesis, several other compounds can also serve as important precursors. One major group includes lactate, which is produced during anaerobic glycolysis in muscles. Lactate is transported to the liver via the Cori cycle, where it is converted back to pyruvate by lactate dehydrogenase and then enters the gluconeogenic pathway. Amino acids, particularly glucogenic amino acids,
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