IGNOU BBCCT 109 2025 - Describe the activation and transport of fatty acids to mitochondria.&

Question

Describe the activation and transport of fatty acids to mitochondria.

14 May 2026

Answer :

Word Count : 344

Fatty acid metabolism begins with the activation of fatty acids before their entry into the oxidative pathway. In the cytosol, or more precisely on the outer mitochondrial membrane, fatty acids are activated by the enzyme fatty acyl-CoA synthetase, also known as thiokinase. This reaction requires ATP and Coenzyme A (CoA), converting a free fatty acid into a high-energy fatty acyl-CoA derivative. The process occurs in two steps: first, the

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