Nursing management of patients with mania and depression involves a comprehensive approach that focuses on maintaining safety, improving mood, enhancing functioning, and promoting medication adherence. The management must be individualized and based on the patient's current phase—either manic or depressive. In the manic phase, patients may present with hyperactivity, impulsivity, irritability, and decreased need for sleep. The primary nursing intervention is to maintain a safe environment. The nurse must assess the patient’s risk for injury to self or others and remove potentially harmful objects. Setting clear, consistent limits is important to manage disruptive behavior. Structured schedules with minimal stimulation are provided to reduce hyperactivity. The nurse must use a calm, firm tone while communicating and avoid arguments. Ensuring adequate rest and nutrition is critical as manic patients often neglect these needs. High-calorie finger foods and fluids are provided to maintain nutrition during episodes of restlessness. Medication management is crucial in mania. The nurse must monitor for side effects and ensure compliance with prescribed mood stabilizers like lithium or valproate,