Question

Discuss how wobble base pairing allows efficient translation with a limited number of tRNAs.

09 Feb 2026
Answer :
Word Count : 222
Wobble base pairing refers to the flexibility in the base-pairing rules between the third position of a codon and the corresponding anticodon of tRNA during protein synthesis. The standard base-pairing between codons and anticodons follows strict Watson-Crick rules, but wobble allows for less stringent pairing at the third codon position. This flexibility is due to the fact that the first two positions of the codon and the anticodon form strong, conventional base pairs, while the third position can tolerate variations.
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