Question

Differentiate between direct and indirect bioassays.

19 Jan 2026
Answer :
Word Count : 54
BasisDirect BioassayIndirect Bioassay
DefinitionMeasurement of the effect of a substance directly on a biological systemMeasurement of the effect of a substance by comparing ____ __________ ____ ______ ___ ____ ____.
__________ _____ ________ _______ __________ ___ _______ _________ ____.
________ ____ ___ ____ ________ ____ _________ __________ ______.
________ ________ __________ ___ _________ ___ __________.
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Related Questions

Explain any five types of biases in clinical trials.

In a quantal assay, the number of cured cases for five doses of a standard and four doses of a new test drug are recorded in the following table:

  d_i} {n_i}$ {r_i}
Standard 3 28 4
  6 30 8
  9 24 12
  12 32 22
  15 27 21
Test 2 31 3
  4 25 9
  6 30 16
  8 25 16

Determine the median effective dose for the standard and test drugs using regression model.

Explain the steps taken for minimising bias in a research setup of a clinical trial.

State whether the following statements are True or False. Give reason in support of your answer:

 

(a) Equality of slopes is the basic requirement for the parallel-line assay.

 

(b) The quantal assay is applicable when the response is the percentage of subjects who responded to a treatment at different doses.

 

(c) A complete life table is more elaborate than an abridged life table.

 

(d) Primary prevention includes strategies designed to reduce the incidence of disease.

 

(e) In Phase II of a clinical trial, we determine a safe dosage range and identify potential side effects.

(a) In a hypothetical study, 10 patients with kidney disease were randomly assigned to receive two dialysis methods (A and B). 5 patients received Dialysis-A followed by Dialysis-B, and the remaining 5 received Dialysis-B followed by Dialysis-A. The kidney function scores of these patients are given as:

  Group-I (AB Sequence)        
Patient No. 1 2 3 4 5
Dialysis-A 69 73 50 69 76
Dialysis-B 68 79 68 72 85
  Group-II (BA Sequence)        
Patient No. 6 7 8 9 10
Dialysis-B 57 70 75 70 69
Dialysis-A 51 71 53 62 64

Test whether the mean score for dialysis-A is different from the mean score of dialysis-B, assuming no carry-over effect.

(b) Describe descriptive and analytic epidemiology.

The number of births occurring in a country in 2015 classified according to age of mother, together with the female population in each group of the childbearing period, is given as follows:

Age Female Population (in '000) Number of Births to the mother in the age group
15 - 19 84.79 2,343
20 - 24 70.01 14,541
25 - 29 72.66 16,736
30 - 34 75.92 10,218
35 - 39 75.10 5,134
40 - 44 71.62 1,422
45 - 49 66.66 93
Total 516.66 50,487

The total population of the country in 2015 was 2285.8 thousand. Using the given information, determine the following:

(i) CBR,

(ii) GFR,

(iii) ASFR for the country in 1958.

Differentiate between direct and indirect bioassays.

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