Healthcare personnel and waste workers are exposed to a wide range of occupational hazards while providing healthcare services and managing healthcare waste. Their safety is closely connected with patient safety because an unsafe workplace can lead to injuries, infections, medication errors, contamination, and transmission of diseases. Therefore, health and safety practices should follow a comprehensive approach based on prevention, risk assessment, training, personal protection, safe work procedures, monitoring, and continuous improvement. The first approach is hazard identification and risk assessment. Healthcare institutions should systematically identify biological, chemical, physical, ergonomic, psychological, and environmental hazards. Healthcare personnel may be exposed to blood and body fluids, infectious microorganisms, radiation, hazardous drugs, disinfectants, sharp instruments, heavy equipment, excessive workload, violence, and workplace stress. Waste workers face additional risks from infectious waste, sharps, toxic chemicals, pharmaceutical waste, pathological materials, poor waste segregation, manual handling, and unsafe transportation. Risk assessment should determine the likelihood and severity of each hazard and establish appropriate control measures. The hierarchy of controls provides an important framework for protecting both healthcare personnel and waste workers. Wherever possible, hazards should first be eliminated or reduced at their source. Engineering controls should then be used, such as safety-engineered needles, closed waste containers, ventilation systems, sharps disposal boxes, mechanical lifting devices, and appropriate waste-treatment equipment. Administrative controls include safe operating procedures, staff rotation, vaccination programmes, infection-control policies, adequate staffing, work schedules, and emergency procedures. Personal protective equipment should be considered an additional layer of protection rather than the only safety measure. Infection prevention and control is particularly important for healthcare personnel. Strict hand hygiene should be practised before and after patient contact and after contact with potentially contaminated materials. Standard precautions should be applied to all patients regardless of their known infection status. Depending on the risk, workers should use gloves, masks, eye protection, gowns, and other