Question
Describe diagnosis and symptoms of:
i) Gout
ii) Phenyketonuria
Answer :
Word Count : 475
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Gout is a metabolic disorder characterized by abnormalities in purine metabolism leading to hyperuricemia and deposition of monosodium urate crystals in joints and tissues. The most prominent symptom of gout is acute inflammatory arthritis, which typically presents as sudden, severe pain, swelling, redness, and warmth in a joint. The first metatarsophalangeal joint of the big toe is most commonly affected, a condition known as podagra, though ankles, knees, wrists, fingers, and elbows may also be involved. Attacks often begin at night and may be triggered by factors such as alcohol intake, high-purine diets, trauma, surgery, or dehydration. As the disease progresses, patients may experience recurrent attacks with increasing frequency and involvement of multiple joints. Chronic gout can lead to the formation of tophi, which are firm nodular deposits of urate crystals found in soft tissues such as the ear pinna, fingers, elbows, and tendons. Renal manifestations including uric acid kidney stones and chronic urate nephropathy may also occur. Diagnosis of gout is primarily based on clinical features supported by laboratory and
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