Climate change has emerged as one of the defining challenges of the twenty-first century, influencing every aspect of human and ecological systems. Its impacts extend far beyond rising temperatures, encompassing shifts in precipitation patterns, sea-level rise, and the increasing frequency of extreme weather events. These transformations complicate the task of assessing vulnerability across sectors such as human health, infrastructure, agriculture, and biodiversity. Vulnerability assessment, which seeks to understand the degree to which systems are susceptible to and unable to cope with adverse climatic effects, is central to developing adaptation and mitigation strategies. However, the dynamic, multi-scalar, and uncertain nature of climate change makes this process highly complex. In the context of human health, climate change has created profound challenges in identifying, measuring, and predicting vulnerability. Health impacts are mediated through both direct and indirect pathways, making it difficult to isolate climate-related risks. Direct effects include heat stress, injuries from extreme weather events, and changes in air quality due to increased ozone or particulate matter. Indirect effects involve shifts in disease vectors, food insecurity, and displacement caused by climatic disruptions. Vulnerability assessments must consider multiple factors—such as age, socioeconomic status, pre-existing health conditions, and geographic location—that determine exposure and adaptive capacity. For example, urban populations living in poorly ventilated, densely populated neighborhoods are more susceptible to heatwaves, whereas rural communities dependent on agriculture may face malnutrition due to crop failures. Moreover, the health infrastructure in many developing countries is inadequate to cope with rising climate-induced diseases like malaria, dengue, and cholera. Assessing vulnerability, therefore, requires integrating epidemiological data, socioeconomic indicators, and climate projections—an undertaking complicated by data limitations, evolving climatic baselines, and varying local contexts. Infrastructure systems—transportation networks, energy grids, water supply, and housing—are particularly vulnerable to the intensifying effects of climate change. Extreme weather events such as floods, hurricanes, and wildfires can disrupt or destroy critical infrastructure, leading to cascading impacts on economies and communities. The challenge in assessing vulnerability lies in the interconnectedness of these systems and the uncertainty of future climate conditions. For instance, coastal infrastructure faces risks from sea-level rise and storm surges, yet