Briefly describe the applications ESR spectral studies.
Application of ESR to Measure Oxygen Free Radicals
The nitrone compound used for ESR spin-trapping can be used to detect (and measure) oxygen free radicals such as O2•− and HO•. Meanwhile, nitroso compounds are mainly used to detect carbon radicals. Desirable characteristics of spin-trapping reagents include high solubility and stability in water, and the ability to interact with free radicals. Furthermore, high reactivity is required to observe the formation of free radicals, while low reactivity is needed to measure elimination activity. It is also desirable that the resulting spin adduct is stable for a relatively a long time and that the spectrum can be easily analyzed.
In our initial studies in 1985, we used DMPO, a high quality agent, as the spin-trapping agent [13], and was supplied from domestic chemical companies. We found that early batches of DMPO imported from other countries had low purity and reacted with blood and living tissues,
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