Question
Acetophenone to 1-Phenyl-1,3-butanedione
Answer :
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The conversion of acetophenone (C₆H₅COCH₃) to 1-phenyl-1,3-butanedione (C₆H₅COCH₂COCH₃) can be achieved by a Claisen condensation (specifically, a crossed Claisen condensation). The reaction proceeds as follows: 1. Formation of the enolate ion: Acetophenone is treated with a strong base such as sodium ethoxide (NaOEt) in ethanol. The base abstracts the acidic α-hydrogen from acetophenone to form the enolate ion: [ C_6H_5COCH_3 + NaOEt \rightarrow C_6H_5C(O^-)CH_2Na^+ +
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