A hypothetical study was conducted on ten participants who were followed up for the development of coronary heart disease (CHD) over a period of 10 years. The recorded data are given as follows:
| Participant ID | CHD Time |
|---|---|
| P1 | 5 |
| P2 | 8 |
| P3 | 2 |
| P4 | 6+ |
| P5 | 9 |
| P6 | 6 |
| P7 | 10+ |
| P8 | 4 |
| P9 | 8 |
| P10 | 4+ |
Estimate the survival function using the K-M method.
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A hypothetical study was conducted on ten participants who were followed up for the development of coronary heart disease (CHD) over a period of 10 years. The recorded data are given as follows:
| Participant ID | CHD Time |
|---|---|
| P1 | 5 |
| P2 | 8 |
| P3 | 2 |
| P4 | 6+ |
| P5 | 9 |
| P6 | 6 |
| P7 | 10+ |
| P8 | 4 |
| P9 | 8 |
| P10 | 4+ |
Explain the Kaplan and Meier method of estimation with an example.
State whether the following statements are True or False. Give reason in support of your answer:
(a) If there are 170 true positive cases out of 200 diseased cases, the sensitivity of the test will be 0.85.
(b) A multiple regression model with three regressor variables was fitted on 15 observations, and the following values were obtained:
Then, the adjusted R2 will be 0.9618.
(c) The method of least squares is used for fitting the logistic model.
(d) The survival function is the probability of an individual surviving less than a specified time t.
(e) If the relative risk for a clinical trial is , the relative risk reduction will be
.
Coefficient of determination and adjusted coefficient of determination.
Chi-square test and McNemar’s test.
To study the relationship between age (in years) and cholesterol level (in mg/dL) of two groups of patients, the following data were recorded:
Group 1
| Age (years) | 46 | 52 | 39 | 65 | 54 | 49 | 76 | 71 |
|---|---|---|---|---|---|---|---|---|
| Cholesterol | 185 | 218 | 182 | 220 | 224 | 193 | 232 | 228 |
| Age (years) | 20 | 33 | 78 | 51 | 43 | 44 | 63 |
|---|---|---|---|---|---|---|---|
| Cholesterol | 180 | 238 | 275 | 244 | 242 | 268 | 260 |
Probit model and Complementary log-log model.