Question

 

 Write various factors which control the formation of enolates.

17 Nov 2025
Answer :
Word Count : 248
The formation of enolates in organic chemistry is primarily influenced by several key factors that determine the extent and regioselectivity of enolate generation. One major factor is the acidity of the α-hydrogen. The more acidic the α-hydrogen, the easier it is to abstract by a base, forming the enolate. For example, ketones with electron-withdrawing groups adjacent to the carbonyl group have more acidic α-hydrogens. The nature of the base is another critical factor. Strong, non-nucleophilic bases such as LDA (lithium diisopropylamide) favor complete deprotonation
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