Question
What do you understand by cholinergic and anticholinergic agents? How do they work? Discuss the common drugs used as cholinergic agents.
Answer :
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Cholinergic agents are drugs that mimic or enhance the action of acetylcholine (ACh), the primary neurotransmitter of the parasympathetic nervous system. They exert their effects by stimulating cholinergic receptors, which are broadly classified into two types: muscarinic and nicotinic receptors. Muscarinic receptors are found primarily in smooth muscles, cardiac muscles, and glands, whereas nicotinic receptors are located in autonomic ganglia and at the neuromuscular junction. Cholinergic agents can be categorized into direct-acting and indirect-acting drugs. Direct-acting cholinergic agonists bind directly to cholinergic receptors and activate them. Examples include pilocarpine, which acts on muscarinic receptors to stimulate
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