Organic Brain Disorders (OBD) are a group of mental conditions resulting from structural or physiological damage to the brain. Conditions like dementia, delirium, and amnestic syndromes are categorized under OBD. In mental health nursing, the care of clients with OBD requires a multidisciplinary and individualized approach, focusing on preserving cognitive function, ensuring safety, and promoting quality of life. Nursing interventions must address cognitive, behavioral, physical, emotional, and environmental needs of the client. One of the primary nursing interventions is cognitive support and stimulation. Nurses should provide reality orientation techniques such as using clocks, calendars, and familiar objects to help the client remain oriented to time, place, and person. Memory aids, structured routines, and repetition assist in maintaining residual cognitive abilities. Activities such as storytelling, music therapy, and puzzles may be introduced based on the client’s functional capacity. Maintaining a safe environment is essential as clients with OBD are at high risk for falls, wandering, and self-injury due to confusion and disorientation. Nurses should remove hazards, ensure proper lighting, and provide supervision during activities. Using bed alarms, identification bracelets, and ensuring that the client’s room is close to the nursing station may help reduce risk. Managing behavioral symptoms is another important intervention. Clients with OBD may show aggression, agitation,