Question
Name the important diuretics. Discuss the mechanism of diuretic actions of any one of them.
Answer :
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Diuretics are drugs that increase the excretion of water and electrolytes from the body through urine. They are widely used in the treatment of hypertension, edema, congestive heart failure, renal disorders, liver cirrhosis, and certain toxicological conditions. Diuretics are classified according to their site and mechanism of action in the nephron. The important diuretics are as follows: 1. Loop diuretics * Furosemide * Bumetanide * Torsemide * Ethacrynic acid 2. Thiazide and thiazide-like diuretics * Hydrochlorothiazide * Chlorothiazide * Chlorthalidone * Indapamide * Metolazone 3. Potassium-sparing diuretics * Spironolactone *
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