Question
Give any two examples of synthetic antimalarial drugs with structure wherein a quinoline moiety is present.
Answer :
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Two important synthetic antimalarial drugs containing a quinoline moiety are Chloroquine and Quinacrine. Chloroquine is a 4-aminoquinoline derivative with the chemical structure 7-chloro-4-(4-diethylamino-1-methylbutylamino)quinoline. It acts by interfering with the detoxification of heme in the parasite, causing toxic heme accumulation and parasite death. Quinacrine,
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