Question
Benzimidazole reacts with formaldehyde
Answer :
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Benzimidazole, a fused heterocyclic compound consisting of a benzene ring fused to an imidazole ring, exhibits nucleophilic behavior due to the presence of the nitrogen atoms in the imidazole ring. When benzimidazole reacts with formaldehyde, an electrophilic reagent, it undergoes a condensation reaction, primarily at the nitrogen of the imidazole ring. The reaction generally occurs under acidic or slightly basic conditions, facilitating the activation of formaldehyde. Initially, the nucleophilic nitrogen of benzimidazole attacks the electrophilic carbonyl
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