IGNOU MCH 17 2026 - Discuss the disconnections for the synthesis of parace

Question

Discuss the disconnections for the synthesis of paracetamol. Also write its scheme of synthesis. Draw the general scheme/mechanism of Stille coupling reaction. Give examples of some additives which are used to increase the rate of these reactions.

01 Dec 2025

Answer :

Word Count : 249

The retrosynthetic analysis of paracetamol involves disconnecting the amide bond to yield *p-aminophenol* and *acetic anhydride* as key precursors. Further disconnection of p-aminophenol traces back to *p-nitrophenol*, which can be obtained from electrophilic nitration of phenol under controlled conditions to ensure para-selectivity. Subsequent reduction of the nitro group, generally by catalytic hydrogenation or metal–acid reduction, furnishes p-aminophenol. Acetylation of this amine using acetic anhydride or acetyl chloride leads to paracetamol through nucleophilic attack of the amine on the acylating agent, followed by proton transfer to stabilize the amide product. The

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