Question
Explain the major pathway of a fatty acid oxidation taking palmitic acid as an example. At which site of the cell do these reactions take place?
Answer :
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Fatty acid oxidation, also known as β-oxidation, is the primary metabolic pathway through which fatty acids are broken down to generate energy. This process occurs in the mitochondrial matrix of the cell. Taking palmitic acid (C₁₆H₃₂O₂) as an example, its oxidation involves several sequential steps:
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Activation of Palmitic Acid – In the cytoplasm, palmitic acid is activated by acyl-CoA synthetase, converting it into palmitoyl-CoA using ATP. This step occurs
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