Question
Explain Negishi coupling reaction with an example and give its mechanism.
Answer :
Word Count : 239
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Negishi coupling reaction is a powerful cross-coupling reaction in organic chemistry that involves the formation of a carbon-carbon bond between an organozinc compound and an organic halide or pseudohalide in the presence of a palladium or nickel catalyst. This reaction is widely used in the synthesis of complex organic molecules, including pharmaceuticals, natural products, and conjugated systems. The general reaction can be represented as R–ZnX + R'–X → R–R', where R–ZnX is the organozinc reagent and R'–X is an aryl or vinyl halide. The mechanism of Negishi coupling involves three main steps: oxidative addition, transmetalation, and
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