Question
Write a short note on transition state analogues, citing two examples.
Answer :
Word Count : 238
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Transition state analogues are compounds that resemble the structure of the transition state formed during an enzyme-catalyzed reaction. During a biochemical reaction, substrates are converted into products through a high-energy intermediate called the transition state. Enzymes stabilize this transition state and lower the activation energy, thereby increasing the reaction rate. Since enzymes bind the transition state more tightly than the substrate, molecules designed to mimic the transition state act as powerful inhibitors. Transition state analogues bind strongly to the active site of enzymes because of their structural similarity
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