What does an oxygen dissociation curve show? Draw and compare the oxygen
dissociation curves of haemoglobin and myoglobin.
The oxygen dissociation curve of adult haemoglobin is a sigmoid curve. The three main points to indicate on the curve are: • Arterial point: pO2 100 mmHg with SaO2 = 97.5% • Mixed venous: pO2 40 mmHg with SaO2 = 75% • P50: pO2 26.6 mmHg with SaO2 = 50%
Four other simple points to remember to allow rapid and reasonably accurate drawing of the ODC in a viva are:
pO2 0 mmHg, SO2 0% - the origin
pO2 10 mmHg, S02 10% - just easy to remember & helps get the sigmoid shape.
pO2 60 mmHg, SO2 91% - the ‘ICU’ point
pO2 150 mmHg, SO2 98.8% - shows flat upper part of ODC
The ‘ICU point’ can be considered as the point on the curve that separates the steep lower
part from the flat upper part. This is a bit artificial but a pO2 of 60 mmHg in this sense is
considered as the lowest acceptable pO2 in an ICU patient because marked
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