Question
In the natural history of a disease define total preclinical phase, detectable pre-clinical phase and clinical phase. Suppose on 09 am on 25.01.2024 a disease A onset you biologically. Suppose a test of disease A can detect it exactly after the completion of 30 days of biological onset. Suppose signs and symptoms develop exactly after the completion of 34 days of
biological onset. Suppose you consult a doctor exactly after 37 days of the biological onset of the disease. Suppose the outcome of the treatment is the cure. What is the duration of the (i) total preclinical phase (ii) detectable pre-clinical phase (iii) clinical phase?
Answer :
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In the natural history of a disease, the phases are defined as follows: * Total Preclinical Phase (TPP): The period from the biological onset of the disease until the appearance of signs and symptoms. * Detectable Preclinical Phase (DPP): The period during which the disease can be detected by a screening test, but before
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