Question
Explain the pathophysiology of following diseases:
(i) Cushing's disease
(ii) Grave's disease
Answer :
Word Count : 346
__________ _______ ________ _______ _______ ______ ______ _______ __________ ___ ________ ______.
______ _____ __________ ____ __________ _____ _________.
_____ ___ ____ _______ __________.
______ _______ ______ _____ _______ ___.
_________ ___ ________ ______ ______ _______ _________ _______ _____ ________ _____ _________.
____ ___ _______ ______ _______ ________ _______ _________ _____ ___ ________ ________.
__________ ______ _____ ________ __________ __________.
__________ ____ _______ _____ ________ __________ ______ _____ ___ _________.
__________ ________ _______ ____ _________ __________ _______ ___ __________ ______.
___ ___ ___ ____ ________ __________ ________ ______.
__________ __________ ____ ___ ______.
___ ____ _______ _______ _____ ______ ____ ___ _________ _________ _____ _____.
______ __________ _____ ______ _________ _____ _____.
________ __________ __________ ______ ______ _____ _______ __________ ________.
________ ___ __________ ___ __________ __________ _____ __________ _________ ___ _________ _______.
____ _______ ________ ______ ___ _______ _______ __________ __________ __________ ______ ___.
_________ _________ ______ __________ ________ _________ ______ ______ _______ _________ _________.
__________ __________ ______ ____ ______ ___ ________ _____ ____ _________ __________ ________.
_____ _______ ______ ___ _________ ________.
_______ _________ __________ ____ _________.
_______ _____ ________ _____ ___ ______ ____ _____ ________ _______ _______ _____.
_______ ____ _____ __________ ______ ____.
_____ _______ _________ _________ __________ ____ __________ _______.
____ _________ ___ ________ _____ _________ _____ ________ _____.
_____ ____ __________ ________ ____ ____ ________ ________ _________ ___.
_______ _________ ___ _______ _________ ___ _______ ____ _________.
________ _________ ________ _______ _____ ______ ___ ____ _____.
_____ _____ _______.
Skip in 10
Cushing's disease is caused by the excessive secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary, usually due to a pituitary adenoma. This elevated ACTH stimulates the adrenal cortex, particularly the zona fasciculata, to produce excessive amounts of cortisol, a glucocorticoid hormone. Cortisol regulates glucose metabolism, protein catabolism, fat distribution, and immune responses. In Cushing's disease, hypercortisolemia leads to increased gluconeogenesis, resulting in hyperglycemia, insulin resistance, and sometimes diabetes mellitus. Proteolysis in muscles causes muscle weakness, thinning of the skin, and easy bruising, while increased lipolysis and fat redistribution lead to central obesity,
___ _______ __________ ____ ____ _________ _________ ______.__________ _______ ________ _______ _______ ______ ______ _______ __________ ___ ________ ______.
______ _____ __________ ____ __________ _____ _________.
_____ ___ ____ _______ __________.
______ _______ ______ _____ _______ ___.
_________ ___ ________ ______ ______ _______ _________ _______ _____ ________ _____ _________.
____ ___ _______ ______ _______ ________ _______ _________ _____ ___ ________ ________.
__________ ______ _____ ________ __________ __________.
__________ ____ _______ _____ ________ __________ ______ _____ ___ _________.
__________ ________ _______ ____ _________ __________ _______ ___ __________ ______.
___ ___ ___ ____ ________ __________ ________ ______.
__________ __________ ____ ___ ______.
___ ____ _______ _______ _____ ______ ____ ___ _________ _________ _____ _____.
______ __________ _____ ______ _________ _____ _____.
________ __________ __________ ______ ______ _____ _______ __________ ________.
________ ___ __________ ___ __________ __________ _____ __________ _________ ___ _________ _______.
____ _______ ________ ______ ___ _______ _______ __________ __________ __________ ______ ___.
_________ _________ ______ __________ ________ _________ ______ ______ _______ _________ _________.
__________ __________ ______ ____ ______ ___ ________ _____ ____ _________ __________ ________.
_____ _______ ______ ___ _________ ________.
_______ _________ __________ ____ _________.
_______ _____ ________ _____ ___ ______ ____ _____ ________ _______ _______ _____.
_______ ____ _____ __________ ______ ____.
_____ _______ _________ _________ __________ ____ __________ _______.
____ _________ ___ ________ _____ _________ _____ ________ _____.
_____ ____ __________ ________ ____ ____ ________ ________ _________ ___.
_______ _________ ___ _______ _________ ___ _______ ____ _________.
________ _________ ________ _______ _____ ______ ___ ____ _____.
_____ _____ _______.
IGNOU ACADEMY
Your IGNOU journey, made easier.
- Solved Assignments
- Study Notes
- Guess Papers
- Question Papers
Continue Reading — It's Free
Sign in with Google to unlock more of this answer.
✓ Free access
✓ Unlock up to 60% of the answer
✓ No payment required
✓ Unlock up to 60% of the answer
✓ No payment required
Quick Google sign-in. No separate registration form.