Question
Explain the factors that affect the O2 dissociation curve.
Answer :
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The oxygen dissociation curve represents the relationship between the partial pressure of oxygen (pO2) and the hemoglobin saturation with oxygen. Several factors influence this curve, shifting it to the right or left, thus altering oxygen affinity. The first factor is pH. A decrease in pH (acidosis) causes a rightward shift in the curve, known as the Bohr effect. This means hemoglobin’s affinity for oxygen decreases, facilitating oxygen release to tissues in need, such as during exercise. Conversely, an increase in pH (alkalosis)
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