IGNOU BBCCT 123 2026 - Describe the role of signal sequences in protein targeting to differen

Question

Describe the role of signal sequences in protein targeting to different cellular compartments.

09 Feb 2026

Answer :

Word Count : 253

Signal sequences are short peptide sequences located at the N-terminus or within the internal region of proteins, guiding their transport to specific cellular compartments. These sequences act as “zip codes” that direct nascent proteins to their destinations, ensuring proper cellular function. For proteins destined for secretion, the endoplasmic reticulum (ER), or organelles like the mitochondria, signal sequences play a critical role in targeting and translocation. In the case of the ER, signal sequences, typically about 15-30 amino acids long, are recognized by the signal recognition particle (SRP) during translation. The SRP

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